Guadalupe Urbina paints with acrylics and oils using paper made from natural fibers in tropical countries. The biggest source of inspiration for her paintings are the creation myths of pre-Columbian Mesoamerica. She paints images that have deep philosophical meaning within rural indigenous or mestizo peoples such as quetzals, butterflies, snakes and trees in both distant and present time.  Stories and songs are based on the myths and imagery of the peoples of pre-Columbian Mesoamerican.  Sequences reflect the story of creation found in cosmogonist Costa Rican thought (including Bri-Bri, Boruca and Guaymi cultures, a living examples of centuries-old resistance to assimilation who have a love for nature), the Pop Vuh, the Book of Wisdom, an ancient Mayan, Aztecan and Mayan codices.